Roles of Lytic Viral Replication and Co-Infections in the Oncogenesis and Immune Control of the Epstein–Barr Virus

Epstein–Barr virus (EBV) is the prototypic human tumor whose continuous lifelong immune control required to prevent lymphomagenesis in more than 90% of adult population that are healthy carriers virus. Here, we review recent evidence this has not only target latent oncogenes, but also lytic replication EBV. Furthermore, genetic variations identify molecular machinery cytotoxic lymphocytes as essential for and studies mice with reconstituted system components (humanized mice) have begun provide insights into mechanistic role these molecules during EBV infection. Finally, often does act isolation cause disease. Some infection-modulating co-infections, including immunodeficiency (HIV) Kaposi sarcoma-associated herpesvirus (KSHV), been modeled humanized mice. These preclinical vivo models infection, lymphomagenesis, cell-mediated do promise a better understanding biology virus, possibility explore vaccine candidates against it.